Jekyll and Hyde Essay Introduction and Para 1

I am going to write an essay on Robert Louis Stevenson’s supernatural story, the strange case of Dr Jekyll and Mr Hyde, which was the inspiration for lots of modern movies showing dual nature of mankind e. g. The Hulk, Two Face and The Nutty Professor to name a few. The story is told mostly in third person by Mr Utterson the lawyer, it is about the scientist Dr Jekyll and his â€Å"friend†, the hated Mr Hyde. Utterson suspects that Hyde may be bribing Jekyll when Jekyll changes his will to one where in the event of his death all his money and his house will be given to Hyde. However when Hyde disappears after brutally murdering the highly respected Sir Danvers Carew, Utterson is pleased, but when Jekyll starts acting weird and will not leave the confines of his cabinet Utterson becomes worried and after Jekyll becomes a recluse and starts making strange demands in a voice that is not his own, Jekyll’s butler and Utterson break down the doctor’s door to find Hyde lying dead on the floor from apparent suicide. The story is later explained in the novella through the testimony of Dr Lanyon, in which he reveals that he witnessed a transformation of Hyde to Jekyll and then explained in more detail by Jekyll. It turns out that Hyde was the result of one of Dr Jekyll’s experiments, where by drinking the ‘transforming draught’ he becomes the hated character who was the complete opposite of his usual self. Over time Jekyll found himself transforming without even drinking the potion, and when the drug ran out he became trapped as Hyde. Upon drinking the very last of the drug Jekyll writes, ‘I bring the life of that unhappy Henry Jekyll to an end’. I thought this book was very interesting and would recommend it to all. This novel is all about the dual nature of mankind. Stevenson believed that every person had a good and bad side to them. The book says a lot about Victorian society as they were all meant to be very good people but really lots of them were corrupt inside. The characters inside this novel show his theory about this very well. For example Jekyll is a well respected man, who was ‘born to a large fortune’ and ‘fond of respect of the wise and good among my fellow men†¦ with every guarantee of an honourable and distinguished future’. Like most people in Victorian society Dr Jekyll was obsessed with respect and he also had an evil side to him. He hated doing â€Å"evil† things such as gambling and drinking so much that he decided to make a potion to split his personality in two. When he first became Hyde, the evil side of his personality he felt ‘younger, lighter and happier in body’ which is because his evil side would not be as developed as his good side as he has done more good than evil in his life. He enjoyed being Hyde because he could do evil things without consequence or people finding out, or so he thought. He felt he did not need to feel guilty about the things he had done as they technically weren’t him.

Kevin Carter Essay

Pulitzer Prize-winning photograph made by Kevin Carter in 1993 I decided to describe the story behind this photograph, because of two reasons. The first one is a book I am reading now: ‘The Bang – Bang Club’. Kevin Carter – the author of this photograph belonged to this four-member club of South African photographers. The second reason is that this is an important moment in documentary photograhy. This photograph was taken during the Sudan Famine in 1993. The picture depicts a hunger stricken child crawling towards a United Nations food camp, located a kilometer away. The child is dying and he won’t make it to the camp. In the background a vulture is waiting for the child to die so it can eat him. The photographer waited for the vulture to spread its wings over the child, but it didn’t happen. Nevertheless, this picture shocked the whole world in 1993. As it turned out, it also took another death-toll – three months after taking the shot Kevin Carter, aged 33, committed suicide due to depression. The photograph first appeared in New York Times on March 26, 1993 and was reproduced in many other newspapers around the world. After the publication lots of people contacted the Times to ask about the fate of the boy. His fate was unknown, but it was almost impossible for him to have reached the feeding center. In 1994, the photograph won the Pulitzer Prize for Feature Photography. It wasn’t the most shocking scene in Carter’s career, as he had been working ear- lier for â€Å"The Johannesburg Star†, being exposed to the real brutality of Apartheid. The publication caused rapid reactions. Carter was bombarded with questions about why he had not helped the child, and only used him to take a picture. He was accused by another newspaper: â€Å"The man adjusting his lens to take just the right frame of his suffering, might just as well be a predator, another vulture on the scene. † In most cases photojournalists say that showing the whole world in its drama is more important that helping starving children at a particular moment, for they will die anyway. It may sound cynical but I believe this is the right thing for them to do. Carter’s photograph started a discussion about the moral aspects of photojournalism. But the author appeared to be its victim. After his death, Carter’s daughter Megan responded: â€Å"I see my dad as the suffering child. And the rest of the world is the vulture. † Photojournalism is a tough profession. Only one member of Carter’s â€Å"Bang – Bang Club† has survived. Others were killed while working or committed suicides, due to stress and depression. The world should have a bit more respect for photojournalists who have been showing us the most important events in the 20th century. Not longer then a week ago the ‘Chicago Sun-Times’ fired all its staff photographers and decided to give reporters some Iphone training†¦ It wasn’t the most shocking scene in Carter career, as he was working earlier for â€Å"Johanesburg Star† being exposed to the real brutality of apartheid.

A play that was written by Arthur Miller in the 1950s Essay

† The Crucible† is a play that was written by Arthur Miller in the 1950s. The play was originally produced in 1953 at a time where McCarthyism was at its peak. This was a time of American paranoia when Americans believed that the Russians were planning start a war with them. The Americans accused members of the society of been a communist spy for the most trivial reasons. It was a situation of hysteria. This was very similar to the situation in Salem two hundred years earlier. The people of Salem would believe anyone to be a witch even if they had very little or no evidence. Salem was governed by theocracy this meant the church ran the local government, therefore they had orthodox religious beliefs. Arthur Miller compares these two situations to show that we all should learn from past mistakes. The past events in Salem contributed to the situation in 1950s America, this shows Causation. The title reflects the play because a crucible is a container used to expose its contents to very high temperatures, this can cause impurities to rise to the surface, it’s metaphoric meaning is a place of severe test or trial. In the play eighteenth century Salem becomes a Crucible, Judge Danforth creates a situation in which he is trying to force the supposed witches to the surface and purify Salem. Miller uses dramatic techniques to maintain the audiences’ interest the message that Miller conveys is to learn from your mistakes and not to jump to conclusions. Abigail changes the way she acts when interrogated by Hale. Abigail has previously been perceived as a dynamic and powerful individual however when Rev. Hale questions her she comes across as very desperate and paranoid. This is shown when Abigail says, â€Å"I am a good girl, a proper girl†. She attempts to make herself out to be a model Puritan, Parris and Hale are manipulated but the audience knows that Abigail is no telling the truth, this is dramatic irony. The playwright Arthur Miller presents Abigail to be extremely deceptive and two-faced, as he wants the audience to dislike her. This is shown when Abigail notices an opportunity to blame Tituba for the unchristian and unlawful activities that she has committed. For instance Abigail blames Tituba for making her laugh in the middle of prayer and for waking her in the night and Abi finds herself naked. Miller does this to give an insight of the sin Tituba is not given the chance to object or justify Abigail’s accusations. An example of this is â€Å"Mister Reverend, I never. † And Hale interrupts her by saying â€Å"Tituba I want you to wake this child. † Reverend Hale is not interested in Tituba’s defence but her satanic influence. This shows that Hale does not pity Tituba he hears that which he wishes to hear. This reveals that the citizens of Salem will believe what they are told, they follow the majority. When Tituba enters the room Abigail immediately puts the blame on her. This shows that Abigail was under a lot of pressure, so much so that she transferred the blame onto the first person that entered the room. Tituba was not expecting Abigail to blame her. She shows this when the stage directions are â€Å"shocked and angry† Tituba previously considered Abi to be a loyal and honest person. Tituba has misinterpreted Abigail’s character. Miller increases the tension as the audience sympathises with the slave since her English is bad and she is been tricked into admitting something she has not done. When Abigail mentions the word â€Å"blood†, Parris Mrs Putnam and Tituba all repeat it. This reveals that the incident that took place in the forest was not as innocent as was first thought. It shows that in fact it was a lot more sinister. The repetition of this key work creates tension since repetition creates a sense of hysteria. Miller reveals this information to increase the audience’s interest. The characters that repeat the word â€Å"blood† are insecure and gullible.

THE NEUROMUSCULAR COMPLICATIONS OF HIV INFECTIONS Essay

THE NEUROMUSCULAR COMPLICATIONS OF HIV INFECTIONS - Essay Example Distal symmetric, often painful sensorimotor polyneuropathy and CMV infection are more common in the late stages of AIDS. 6. AIDP and CIDP may be the initial manifestation of disease, related to autoimmune dysfunction. CSF shows pleocytosis and increased protein. Nerve conduction studies (NCSs) and biopsy are compatible with demyelination. 7. Mononeuropathy multiplex is an inflammatory response in the early stages of disease. Late MM is typically associated with CMV infection. May appear as IDP or PP. EMG and NCS show axonal degeneration and asymmetric involvement. SDF shows pleocytosis and elevated protein level. 8. Progressive polyradiculopathy (PP) is typically associated with CMV and herpes infections. Highly active antiretroviral therapy (HAART) has reduced the incidence of PP. CSF shows pleocytosis and elevated protein level. It typically presents with a cauda equina–like picture, and EMG shows denervation of the lower extremities. NCSs are mildly slow. 10. Myopathy shows proximal weakness and is confirmed with EMG. Elevated CK may also be seen, and muscle biopsy can be helpful, demonstrating necrosis and inflammation. HIV-related myopathy must be differentiated from toxin (AZT) related myopathies. (1) Peripheral neuropathy is the commonest neurological disorder associated with HIV infection. Though symptomatic peripheral neuropathy is observed in 10% to 15% of HIV infected patients, pathologic evidence of involvement of peripheral nerve is seen almost all cases of end-stage AIDS patients. Although the pathogenesis of distal sensory polyneuropathy is unclear, the condition is associated with deterioration of the patients immune system. A primary viral etiology is unlikely, since Human Immunodeficiency Virus does not infect peripheral nerve Schwann cells or axons. The similarities in clinical and pathologic findings of HIV-associated distal sensory polyneuropathy (DSP) and vitamin B12 deficiency-related

Stem Cell Rubric Research Paper Example | Topics and Well Written Essays - 1000 words

Stem Cell Rubric - Research Paper Example However, there are certain advantages in using embryonic stem cells (ESC) that the others still cannot provide. Unlike ESC that are known to come from pre-implanted embryos, the source of ASC is still to be discovered. By some reason still unknown to researchers, ESC proliferate and remain undifferentiated for a year longer than ASC do. In addition, ESC have the potential to differentiate into all cell types of the body, while ASC can only differentiate into the cell types of its tissue of origin. Also, it is much easier to increase the number of ESC than that of ASC (National Institutes of Health, 2009). For example, if it is hematopoietic ASC, then it can only be induced to form blood cells. However, despite the seemingly more advantageous ESC, ASC are believed to induce less graft transplantation reaction, as it can be derived from the patients themselves (National Institutes of Health, 2009). Benefits of Stem Cell Research Arguably, the most important benefit of stem cell researc h is the use of these cells in stem cell transplantation therapy. In fact, for 40 years already, hematopoietic or blood-forming ASC from bone marrow have been used in transplants to cure health conditions such as leukemia (National Institutes of Health, 2009). ... It is important to develop therapies for these illnesses, especially cancer and cardiovascular diseases, as these occupy the top of the list of morbidity and mortality worldwide. Aside from that, further stem cell research (SCR) paves the way for more discoveries, such as the regulating factors behind stem cell proliferation and self-renewal. These factors, in the future, may be used in the regeneration of destroyed tissues, such as that in myocardial infarction, one of the leading causes of morbidity and mortality in the United States. In addition, these pluripotent cells can provide a better observation of human development from embryo to infancy. This then may lead to researches on the abnormal cellular development, as seen in physical birth defects, genetic abnormalities and cancer. Large amount of cells grown in vivo from stem cells may also be used in easier and safer testing of drug safety and effectiveness (Johnson and Williams, 2006). Disadvantages of Stem Cell Research Whic h Lives to Save Despite the many scientific advancements contributed by stem cell research, many still argue against it. One argument reasons that the fertilized eggs used in SCR are already alive, and thus it is not right to take someone else’s life, no matter for what purpose. Partly causing such conflict stems from the fact that until now, there is no specific age of gestation at which life has been pinpointed to start at. The Health Risk of Stem Cell Therapy Another argument against SCR claims that the chemical and biological factors used to manipulate the cells in vivo can cause adverse effects once the resulting specialized cells from them are transplanted to humans for therapy. For example, viruses from the

Health care crisis Essay Example | Topics and Well Written Essays - 750 words

Health care crisis - Essay Example Health insurance is a crucial component in the health care system of Americans for unusual, expensive, and unpredictable events. It poses problems if it is used as a payment method for the everyday health care. Americans have been forced to pay more for health insurance but in return are receiving less. Kaiser Family Foundation (2010) states that, â€Å"American families arent only paying higher deductibles, but higher copayments as well; in 2004, only one in five people with health insurance through an employer had a copayment of more than $25; in 2008, that number was one in three and in 2009, it was nearly one in two.† Many researches and stakeholders argue that the current state of primary health in America care is unfair, corrupt, and devious and thus requires dire need of reformation. Statistics indicate that over 47 million of Americans lack health care insurance because of the high costs involved. For instance, about 2.4 trillion dollars was spent on health care in the year 2008 but it is estimated to rise to 4.3 trillion dollars by 2016. This is said to be four times the National Defense budget. This thus implies that every time the tax rates increase the unemployed people are injured and their medical costs need to be paid. Kaiser Family Foundation (2010) argues that, â€Å"The costs of employer-based health insurance premiums have  risen 114% since 2000; Americans are paying higher deductibles with the average family deductible increasing from $1,034 in 2006 to $1,518 in 2010.† Either the middle income families with individual health care insurance coverage spends about 22% of their household income while middle income families with employer based health insurance coverage spends about 8% of their household income. Thus, many Americans families are going without health care insurance coverage because of the escalating costs, gaps in quality and in access to health care. These rising cost are making innocent

How to solve problem of organization Essay Example | Topics and Well Written Essays - 1000 words

How to solve problem of organization - Essay Example Personnel may be in the wrong job because they lack the relevant skills required, lack initiative or job hunting skills to find a job that suits their skills or stay in a job considered suitable for them. These issues result in a lot of problems within an organization. Research conducted in Kuwait found that the problem is quite rampant. This paper will examine the proper problem solving mechanisms to tackle the problem of wrongful placement of workforce. Being in the wrong job is damaging to an individual and the organization, as well. The process of solving organizational problems entails five key steps. These include finding the problem, formulating the problem, deciding on the solution, implementing the solution and reviewing the results. After company management identifies and formulates the problem, i.e. the organizational problem of wrongful personnel placement, they should find viable alternatives to counter the issue. While organizations encounter a multitude of problems, the problem of wrongful employee placement causes the most harm to the organization (Smart & Street, 2008). However, it is often the executives that fail to comprehend the impact of a poor performer. It is the colleagues of such an employee who experience the consequences of wrongful personnel placement. This breeds destructive employee drive and loss of productivity. One of the factors that result in wrongful employee placement include loyalty, for instance, when a manager employs a friend making it difficult for the employer to identify the right position for that employee. In addition, after evaluating and formulating the problem, management can solve the problem of employees working in the wrong position by ensuring that hiring is done on a professional rather than personal basis. Employing friends or relatives who are unqualified for a position on the basis of loyalty may damage

Feminism in Literature Essay Example | Topics and Well Written Essays - 2250 words

Feminism in Literature - Essay Example Men had more rights, and it seemed to be the most natural thing. The term "feminism" generally meant "the qualities of females during the mid-1800s. (Sally Haslanger; Topics in Feminism, Stanford Encyclopedia of Philosophy) But in a way, it sort of distinguished women from men and may have led some women to start comparing the rights and roles attributed to both. After the First International Women's Conference in Paris in 1892, the term "feminism" came to mean "the belief in and advocacy of equal rights for women based on the idea of the equality of the sexes." (Sally Haslanger; Topics in Feminism, Stanford Encyclopedia of Philosophy) "On the wave model, the struggle to achieve basic political rights during the period from the mid-19th century until the passage of the Nineteenth Amendment in 1920 counts as 'First Wave' feminism. Feminism waned between the two world wars, to be 'revived' in the late 1960s and early 1970s as 'Second Wave' feminism. In this second wave, feminists pushed beyond the early quest for political rights to fight for greater equality across the board, e.g., in education, the workplace, and at home. More recent transformations of feminism have resulted in a 'Third Wave'. Third Wave feminists often critique Second Wave feminism for its lack of attention to the difference among women due to race, ethnicity, class, nationality, religion, and emphasize 'identity' as a site of gender struggle." (Sally Haslanger; Topics in Feminism, Stanford Encyclopedia of Philosophy) No doubt, feminism was meant to be founded and rallied for by women - it was just a question of which age in the history of the world it was destined to finally be started. No doubt, women were destined to know there is more to life that what it had to offer them during the dark ages when the world was mostly the men's world. A.2 The Major Issues and Concerns of Feminism There have been many published definitions of feminism, and there have been varying causes that feminism, as represented by different groups of women, has lobbied for. One general statement about feminism goes as follows: "Feminism is both an intellectual commitment and a political movement that seeks justice for women and the end of sexism in all forms." (Sally Haslanger; Topics in Feminism, Stanford Encyclopedia of Philosophy) Justice for women, though, cannot always be easily determined - because women do not always compose one unified and solid group. This is because of the many varieties and differences that can be used as divisions - this can be both good and bad. When done in a logical and organized way that is accepted by everybody as binding and fair, then the further formation of small groups within the whole all-encompassing group would have meant strength in terms of unity and solidarity in the face of many issues and problems of the society. Feminism may be deemed as simply protecting the interests of women or fighting for their equal rights with men. "However, there are many different kinds of feminism. Feminists disagree about what feminism consists in, and what exactly ought to be done about it; they disagree about what it means to be a woman or a man and

HR Planning Process Assignment Example | Topics and Well Written Essays - 250 words - 1

HR Planning Process - Assignment Example One such method is recognized as the personality test (Hill, 2007). This test is used in order to identify whether an applicant’s personality matches the personality that is required for a particular position. For example, a sales person is required to have an extrovert personality in order to easily communicate with other and persuade them to purchase organization’s goods and services. Personality test can even be used by organizations in order to identify whether the incumbent suits the culture of the organization. This will help in ensuring the there is no conflict between the employees and the culture of the organization and the organization operates smoothly. Another method for employee selection that can be used is the job sample test (Hill, 2007). In this test, applicants are required to perform a particular job or a particular part of a job. This selection method is used to ensure that the person being hired knows how to work in the position for which he/she has applied. This will help the organization in attaining the objective of decreased expenditure on training and development that an organization may have to spend to prepare an individual to perform that particular

Illegal use of VOIP Essay Example | Topics and Well Written Essays - 1500 words

Illegal use of VOIP - Essay Example According to the essay the principle behind VoIP is that using a computer and a microphone it is possible to record sound of a person. In this process, the sound would be sampled at a very high rate and then would be stored as files in the computer. Each of these samples is a small bit of sound by the respective person. Now the computer would be able to use these samples in such a way that a listener would be able to hear accurately what the speaker has said. In VoIP, the difference is that the recorded samples are send through IP services to another computer placed at a distant place. So the speaker’s voice could be heard as such by a listener sitting at a long distance. As the paper presents VoIP system could be installed in a variety of hardware systems such as a telephone. There is no need of a computer in that case. Some of the VoIP providers allow a customer to contact only a person using the same service. But there are providers who would allow contacting any person with a telephone number and this include land line or mobile or international or long distance numbers. Instead of a computer one could use a VoIP telephone for the purpose. The traditional telephone available with the customer could be used for the purpose with a VoIP adapter. In this case the digital signals of sound would be converted into regular telephone signals before it reaches destination. ... So IP packets would be containing a lot of samples each with a bit of sound and together they form the entire message. If these packets are delivered in the correct time satisfactory results could be obtained. But if it is delayed, it has to be discarded. The process of compression, transmission, the processes by which it is uncompressed and delivered have to take place in a very less time. If the process is delayed or is not occurring according to time there would be echo or over talk (VOIP disadvantages, 2009). VoIP system could be installed in a variety of hardware systems such as a telephone. There is no need of a computer in that case. Some of the VoIP providers allow a customer to contact only a person using the same service. But there are providers who would allow contacting any person with a telephone number and this include land line or mobile or international or long distance numbers. Instead of a computer one could use a VoIP telephone for the purpose. The traditional telephone available with the customer could be used for the purpose with a VoIP adapter. In this case the digital signals of sound would be converted into regular telephone signals before it reaches destination. Above all these in areas where wireless internet connections are possible like in airports, cafes etc, VoIP service could be availed wirelessly (Voice-Over-Internet Protocol, 2009). This makes illegal calls very easy to be made. There is no need of spending money on expensive devices for VoIP services. Without much expenditure, using the existing phone one could easily make long distance calls through VoIP and for the same reason it is difficult for the government to interfere to reduce such illegal practices (How does VoIP works, 2009). According to Burns (2007) in China the

Term Paper About Sports Essay Example for Free

Term Paper About Sports Essay The sport datesback to the Egyptians, who played games involving the kicking of a ball. Now, the sport has grown to a global pastime, including men s and women steams, and the World Cup (which is played every four years). The sport is also known by other names in some parts of the English-speaking world, usually association football and its contraction, soccer. These names are often used to distinguish the game from other codes of football, since the word football may be used to refer to several quite different games. Football is a team sport played between two teams consisting of eleven players each. It is a ball game played on a rectangular grass field with a goal at each end. The objective of the game is to score by maneuvering the ball into the opposing goal. Other than the goalkeepers, players may not use their hands or arms to propel the ball in general play. The winner is the team which has scored most goals at the end of the match. Football is played at a professional level all over the world, and millions of people regularly go to football stadia to follow their favourite team, whilst billions more avidly watch the game on television. A very large number of people also play football at an amateur level. According to a survey conducted by Federation Internationale de Football Association (FIFA), footballs governing body, published in the spring of 2001, over 240 million people regularly play football in more than 200 countries in every part of the world. Its simple rules and minimal equipment requirements have no doubt aided its spread and growth in popularity. In many parts of the world football evokes great passions and plays an important role in the life of individual fans, local communities, and even nations; it is therefore often claimed to be the most popular sport in the world. Because of this it is often dubbed as the Worlds Favorite Pastime. 1. Football is rougher than most people actually think. People usually dont see whats happening outside the television camera’s view or off the field. Off the screen, you have players kicking each other, exchanging words, or even pushing each other around. Dont feel bad, though, because the referees dont see it half the time either. Then, during the game you have players slide tackling and taking each other out for possession of the ball. These players are wearing nothing to protect them from serious injuries. According to a survey conducted by Federation Internationale de Football Association (FIFA), footballs governing body, published in the spring of 2001, over 240 million people regularly play football in more than 200 countries in every part of the world. Its simple rules and minimal equipment requirements have no doubt aided its spread and growth in popularity. In many parts of the world football evokes great passions and plays an important role in the life of individual fans, local communities, and even nations; it is therefore often claimed to be the most popular sport in the world. Because of this it is often dubbed as the Worlds Favorite Pastime. 2. II. History of Football (Soccer) During the 1800s the people of England played a game similar to soccer. Many rules changed and each person interpreted the rules differently. The modern version came about in the early nineteenth century,in England. It started as a game involving kicking and handing, but later this branched off into two separate sports: rugby and football (which is what the English call soccer). In 1848 a group of school representatives met at Trinity College in Cambridge and drew up the first of soccer rules. In 1863 English soccer clubs founded the Football Association. By the late 1800s soccer began to spread to the rest of the world. The Canadian Soccer Association was established in 1912 while the United States Soccer Federation was set up in 1913. The first World Cup Championship was in Montevideo, Uruguay. Since then it has been played every four years except during WWII. The North American Soccer League (NASL) was formed in 1968 and the sport began to gain popularity in the 1970 s. Modern Game and Rules The modern game of soccer has a simple goal: kick or head the ball in to the goal of your opponent s team. Basically, there is also one simple rule: No one except the goalkeeper may use they rehands to play the ball. Soccer is a simplistic sport. Eleven members of each team defend their side of the field to prevent the ball from being forced into their goal, which results in a point scored by the team kicking the ball. There are only three officials involved during play: The referee, and two linesmen. The equipment used in soccer is also very simple. In addition to the field itself, all that is needed for a game is two goals (eight feet high and eight yards apart) and a ball. Each player wears hard plastic or padded shin guard, covered by long socks, for protection during play. Cleats are alsoworn for traction on the field. A goalie may also wear a special padded shirt,and gloves to protect his or her hands. A standard field, as regulated by the Federation International de Football Association (or FIFA), has a length between 100 and 130 yards,and a width of between 50 and 100 yards. The rules of play for soccer have deliberately been kept simple. The referee makes most of the decisions, and attempts to encourage fair play. A soccer or football game begins with a kickoff in the center of the field. A coin is flipped to decide which team will kickoff. The other team kicks off at the start of the second half when the teams switch sides or nets. 3. III. Nature of the game The game is played in accordance with a set of rules known as the Laws of the Game, which are summarised below. Two teams of eleven players each compete to get a round ball (itself known as a football) into the other teams goal, thereby scoring a goal. The team which has scored the most goals at the conclusion of the game is the winner; if both teams have an equal number of goals then the game is a draw. The primary rule for this objective is that players, other than the goalkeepers, may not intentionally touch the ball with their hands or arms during play (though they do use their hands during a throw-in restart). Although players mainly use their feet to move the ball around, they may use any part of their bodies other than their hands or arms. The physical contact between players is restricted: holding, tripping, kicking or excessively pushing opponents is not allowed. Such actions (along with handling the ball) are called fouls and are punishable by a free kick (or a penalty kick if commited in the vicinity of the offenders goal; see below for details). In typical game play, players attempt to move towards a goal through individual control of the ball, such as by dribbling (running with the ball close to their feet); by passing the ball from team-mate to team-mate; and by taking shots at the goal. Opposition players may try to regain control of the ball by intercepting a pass or through tackling the opponent who controls the ball. Football is generally a free-flowing game with the ball in play at all times except when the ball has left the field of play by wholly crossing over a boundary line (either on the ground or in the air), or play has been stopped by the referee. When play has been stopped, it recommences with a specified restart (see below). At a professional level, usually a few goals are scored during a match. For example, during 2004-05 season of the FA Premier League, an average of 2. 57 goals per match were scored, and 88% of the matches ended up with not more than 4 goals scored. However, only 8% of the matches finished goalless. 4. IV. Playing Area An  association football pitch  (also known as a  football pitch,  football field[1]  or  soccer field) is the playing surface for the game of  association football  made of turf. Its dimensions and markings are defined by Law 1 of the  Laws of the Game, The Field of Play. [2] All line markings on the  pitch  form part of the area which they define. For example, a ball on or above the  touchline  is still on the field of play; a ball on the line of the goal area is in the goal area; and a foul committed over the 16. -metre (18-yard) line has occurred in the  penalty area. Therefore a ball must completely cross the touchline to be out of play, and a ball must wholly cross the goal line (between the goal posts) before a goal is scored; if any part of the ball is still on or above the line, the ball is still in play. The field descriptions that apply to adult matches are described below. N ote that due to the original formulation of the Laws in England and the early supremacy of the four British football associations within IFAB, the standard dimensions of a football pitch were originally expressed in  imperial units. The Laws now express dimensions with approximate  metric  equivalents (followed by traditional units in brackets), but use of the imperial units remains common in some countries, especially in the United Kingdom. 5. V. Physical (Soccer/Football) Conditioning Soccer is a sport requiring high levels of physical fitness. It is one of those rare games which demands not only speed but agility, strength, power and endurance. Players at top levels can run over 14 km in a game whilst not forgetting the frequent accelerations, decelerations, changes of direction and jumps they must undertake. Fitness is important at all levels of the game, whilst being essential for top level players, it is beneficial for beginners who will improve both their effectiveness and enjoyment through good standards of fitness. The aim of fitness training in football is to enable a player to cope with the physical demands of the game as well as allowing the efficient use of his various technical and tactical competencies throughout the match. Fitness may be described as a set of attributes that an individual has or has acquired which help in their ability to perform physical activity. The diagram below (Fig 1) outlines the general components which make up and are required for physical fitness in sport. Mental fitness and diet could be included but the diagram refers to the main components of fitness which require physical activity and which bring about physiological changes in the body. | Fitness as mentioned earlier is based on the attributes an individual has, meaning what he is born with or has acquired, in other words through training. Thus, performance is influenced by inherited abilities (genetic) and training status. An individual who is naturally gifted will still need proper training to make the most of their talent. Different sports require different fitness components. Football players must be able to perform prolonged intermittent exercise (endurance), exercise at high-intensity, sprint, and develop high levels of power (force) when kicking and tackling. Good levels of agility and coordination are also necessary and distinguish between elite and average players. During a game the exercise intensity varies continually thus fitness training should be as realistic as possible. Training should also involve regular use of the ball as this will not only help develop the specific muscles involved in match play, but improve technical and tactical skills and help keep players interested. 6. Coaches such as Marcello Lippi formerly at Juventus, are big believers in individual fitness programs as every player has different needs. This is important as well when training women and youth players. Fig 2 details the major components involved in football specific training. | In all the different components of fitness mentioned above, there are certain basic principles that apply to football fitness training. Frequency   Refers to the quantity of training sessions during a defined period of time, often a week. For example, a professional player may train twice a day, 5 times a week. Intensity   Can be simply defined by how  hard  a player trains. Too much exercise can lead to injury and fatigue whereas too little will not have enough of an effect. Elite players can train longer and harder than players at a lower level. Intensity is often based on the number of repetitions and how many exercises/sets done. It is linked to the principle of progressive overload. Progressive overload amp; duration   Training programs should stress the players’ physiological mechanisms enough to cause an improvement in the desired area. This means that working on the same fitness programme for a long time will not bring about improvement. Therefore, training status will only be bettered by gradually increasing the load that the body is working against. Incorrect overload may bring injury and demotivation due to over-zealous targets. The duration is the time spent in a training session and is dependent upon the sport and individual.

India Unity Essay Example for Free

India Unity Essay India is land of variety. There is great variety in variety of aspects. The languages, lifestyles, religions, habits, geography, climates, cultures might be different but still they unite us into an invisible frame, the frame of Indianism. Diversity is there in every aspect of India, a land that encloses 1,222,559 sq. meters of land and is home to more than one billion people. As such stats imply, there ought to be diversity, but this does not always imply that there are differences. Rather, India is a land where in spite of so much of diversity, there is still unity. Be it the joining of hands for a mission or against it, Indians have always shows great unity. There have also been instances where people have fought against each other for some reason or the other but such cases do break out in all countries, so India being a niche of such diversity can be excused for once! India wont be India if not for this diversity. If India means Kanchivaram sadi then India also means Pashmina shawl. If India means extreme hot climate of the south India, then India also means the snow covered mountains of the north India. If India means the desert of Rajasthan then India also means the highest rainfall grounds of Assam! Such diversity is also found in the school of minds, where one stands for the motion, another stands against it. This means an added advantage, because while one is looking at the positive aspects of a side, other is hunting for the counterpart negatives. The diversity of India has a great edge over the plain unanimously joint countries! It might be speculated that is just another starry eyed optimist opinion, but then if we didnt differ wouldnt we be non-Indians

Investigation of Single Chain Sugar-based Glycolipid

Investigation of Single Chain Sugar-based Glycolipid Review on Investigation of Single Chain Sugar-based Glycolipid Self-Assembly in Lyotropic Phase Using Fluorescence Spectroscopy M.Faisal Khyasudeen* KEYWORDS (Word Style â€Å"BG_Keywords†). If you are submitting your paper to a journal that requires keywords, provide significant keywords to aid the reader in literature retrieval. ABSTRACT: Glycolipid in lyotropic phase has been widely study due to its nature similar to those in biological membrane. This uncharged amphiphilic molecules has been used in cosmeceutical industry as an emulsifier and as nano-carrier in pharmaceutical industry. Some of the reason on its application is because of its features such as low toxicity on environment, biodegradable, specific sugar-cell recognition as well as relatively cheap in production. Vesicle formation by the single chain glycolipid allow high efficiencies of drug delivery by the effective encapsulation of the active material until it reached the specific target cells. In this report, fluorescence studies using different probe were discussed to understand the stability and degree of flexibility of the lipid for its self-assembly. Tryptophan (Trp) with its ester derivatives (Trp-C4 and Trp-C8) are examples of probes to study the glycolipid hydrophilic head while pyrene molecules to gain insight of the hydrophobic group . Steady-state fluorescence indicate a reduction in polarity gradient from polar domain to the non-polar domain resulted from sugar head group and hydrocarbon tail respectively. While fluorescence lifetime measurement for the probes uncover an extra information such as ability to form two different rotamer or any heterogeneity arises due to flexibility of lipid self-assembly. Specifically, this review will be emphasized on characterization of glycolipid with probes component and how in turn these are related to the nature of self-assembly for the glycolipid. INTRODUCTION Amphiphiles are molecules that have a hydrophilic head and a hydrophobic tail. Because of this, amphiphiles when mixed with water is capable of self-assembly into a wide range of different structures with a variety of properties. Shown in Figure 1 are some examples of such structures [1, 2]. They include the lamellar structure, where the amphiphiles self-assemble to give a sheet like structure; the micellar phase where the amphiphiles form a spherical structure with a hydrophilic exterior and a hydrophobic interior; the hexagonal structure where amphiphiles form micellar cylinders that are stacked in a hexagonal lattice; and a whole family of cubic structures, which resembles pipe joints linking cylindrical micellar units. This lyotropic mesomorphism is exhibited by many amphiphiles [3]. The amphiphile systems can transform between these mesophases depending on the relative amphiphiles/water concentrations, salt concentrations, pH, temperature and pressure. Apart from the aesthetics of the various structures, the versatility of some of these amphiphiles structures has also been of great scientific importance and utility. For example, our body is made of 10^13 cells that are constructed from complex membranes self-assembled from amphiphilic phospholipids [4]. Lipids such as monoolein in its cubic phase has been used to crystallize membrane proteins, thus making possible their x-ray diffraction structure determination [5]. Similar lipids have also been used for drug delivery purposes [2]. Another example is the glycolipids [1], which form minor but integral components in the cell membranes of prokaryotes and eukaryotes, and are responsible in maintaining structure integrity in cells. Figure 1. Phase change in the Glycolipid self-assembly by changing the temperature of the system Glycolipids are one of the examples in large family of glycoconjugates in which the sugar head group is bonded to hydrocarbon chain. It is an amphiphilic molecule derived from the carbohydrate headgroup whereas the hydrocarbon tail builds up the hydrophobic part of the molecule. The glycolipids can exhibit liquid crystals properties and have mesophase behaviour. The advantages of using sugar-based non-ionic surfactants compared to the usual surfactants because they are highly biodegradable, environmentally friendly, and less toxic [2,3]. Besides that, they are also much cheaper, and have diverse biological activity. Figure 2. Example of probe used Alkyl glycoside has been used for numerous surfactant application. Microemulsion form by these nonionic surfactant will help in dispersing the water and oil in continuos phase. Direct application such as detergent and cleaner has been use including alkylpolyglucoside (APGs) where it is reported that APGs improves the foam properties of the product according to IPP quality standard. In addition, one development of alkyl glycoside which is still in its infancy is on its application as vesicles for drug delivery carrier as reported by Kiwada and co-workers. It is reported that high entrapment efficiencies of the anticancer drug with prolonged in vitro drug released particularly in spleen and liver were shown using alkyl glycoside as nano-carrier. Furthermore, it reported by Rauzah.H and coworker, the use of similar vesicle to enhance the drug skin penetration using maltosylated and lactosylated alkyl glycoside. Understanding the various factors that contribute to the stability of these different lipid phase structures will be important in further applications of these fascinating objects. One important factor that determines the stability of the various phases in different conditions are the hydrogen bonding networks of the water environment surrounding the amphiphile’s hydrophilic headgroup. In this report, fluorescence studies using steady state and time-resolved measurement were discussed in guiding to correlate the behavior of the probes with the local environment of the glycolipid. Columnar phase of an aqueous formulation of the single chain alkyl glycoside such in the example depict in figure 3 were reviewed due to the ability of it to form in wide range of concentration and temperature (cite the phase diagram). Since lipid membrane usually do not possess any intrinsic fluorescence, it is common to used extrinsic associating probe which strongly sensitive to its surrounding environment. One of the most common membrane probe is tryptophan and pyrene. Trp is used as a local reporter for hydrophilic head and pyrene which is non-polar molecule to probe in hydrophobic region. Figure 3. Example of chemical structure of single chain glycolipid. DISCUSSION One of valuable property of fluorescence probe is in their sensitivity towards different polarity gradient. Fluorophore such as trp shows a shift spectrum in steady state measurement correspond to change in dielectric constant of solvent. Spectrum shift as in Figure 3 reported by (Idayu paper) for both glycolipid, shows that the trp peak maxima shift towards the blue side by decreasing the solvent polarity. This is due to the solvent effect which cause the stabilization of excited state by the higher dielectric constant of solvent molecules. As explained in (prof Lakowicz), normally, fluorophore possess a higher dipole moment in the excited state compared to in the ground state. Thus the solvent dipole can relax to lower the energy of the excited state after the absorption process. The reported unstructured fluorescence is due to the 1La state while the structured fluorescence is reported to be in 1Lb state. The state in 1La is a solvent sensitive state towards the polar nitrogen ato m indole group in tryptophan. (1a) Steady-state and lifetime measurement for hydrophilic head using tryptophan with its derivatives Steady state spectrum of tryptophan and its ester derivative (Trp, Trp-C4, and Trp-C8) together with the lipid embedded were reported by (idayu paper) in n-dodecyl ÃŽ ²-D-maltoside(ÃŽ ²MaltoOC12) and octyl ÃŽ ²-D-glucoside(ÃŽ ²GlcOC8). From the fluorescence spectrum, it is clear that when the tryptophan and its derivative embedded in lipid shows almost a similar pattern as depict in figure 3. The spectra observed shift to the blue side relative to that in buffer. This indication explain the different local environment senses by tryptophan and its derivatives in the lipid system. By comparing the two spectra, tryptophan molecule shows less polar environment as compared to bulk water. This can be seen across the increasing chain length of the tryptophan ester. Due to increasing hydrophobic nature of the tryptophan moiety (trp C-4 and Trp C-8), it is pronounced that the tendency of the tryptophan penetration across the membrane will be also increase. Consequently, indole group in trypto phan will be attracted closer to the amphiphilic head of the glycolipid. Correlation between the fluorescence peak of tryptophan in lipid and in solvent predict the different in water profile across the aqueous nanochannel. The observation complement to the result that are reported by Dongping zhong and coworker, showing confined water in aqueous nanochannel can be divided into three distinct time scale;(1) ~100-150 ps correspond to two layers of well-ordered interfacial water which dynamically is a rigid water molecule. In this region, the solvent network which allow for water molecule to form intermolecular interaction with more than one water molecule were perturbed. This reduced the local polarity senses by the tryptophan ester similar to the peak maximum in 1,4-dioxane which is highly non-polar solvent. (2) 10-15 ps, correspond to quasi-bound water motion. This can be observed similar to the previous case where the tryptophan moiety resembles to those in methanol and ethanol. ( 3) 1 ps and lower, showing the bulklike near the channel centre where the environment shows the highest polarity similar to that in buffer. Basically the (1) and (2) is important in maintaining the global structure stability of the glycolipid and the flexibility to adapt different structure such in phase diagram. On lifetime of Trp in 10-9 magnitude (1 ns or higher), two different lifetime component is usually correspond to the exhibition of different rotamer (rotational isomer) by the Trp moiety. These result point to a degree of flexibility of the lipid self-assembly that allow the Trp side chain to adapt two different rotamer (1b) Steady State and lifetime measurement for hydrophobic tail using pyrene as probe. Investigation of tail region using pyrene as a probe were reported to be sensible in less polar environment due to the non-polar characteristic of the pyrene. The favour of pyrene can be explained by observing the spectrum shift in different dielectric constant of solvent as reported by (idayu) in figure 6. Solvent such as cyclohexane shows a blue shift as compared to that in buffer. The peak between 360nm-450nm indicate formation of monomer by the pyrene while the peak maxima around 465nm is due to the formation of excited dimer (or excimer) (cited Lakowich ngan paper lain) even at a very low concentration (0.05mM of pyrene). In a polar condition, it tend to form dimer because of the hydrophobic nature of pyrene which disliked polar solvent and thus forming a cluster to reduce the surface contact with the molecule of the solvent. The spectrum as shown in figure 7 in (idayu paper) shows a complete absent of dimer in the lipid. Pyrene molecule was said to be dispersed in the tail regi on as monomer and tend to isolate from each other. Additional information from the fluorescence spectrum of pyrene is the (I1/I3) ratio which correspond to the vibronic transition of 0-0 band. The value for the ratio of peak 1 and 3 indicate local polarity of the environment that the pyrene experienced. In principle, high value of (I1/I3) indicate more polar environment. Some examples for the values of (I1/I3) in different solvent and lipid composition were shown in the table 1, Table 1. Value of ratio (I The result of pyrene in lipid shows an intermediate between the value as in buffer and cyclohexane. However, the ratio shows a closer number towards the buffer solution which further indicate the favorable of pyrene to locate near the lipid head group. This was proved by the simulation worked done by (Prof rauzah. Embedding the tryptophan and pyrene together result in reduction of polarity based on the value dropped by 0.02 as compared with only single component of trp-C8 in lipid. The reduction of polarity in presence of trp-C8 is because of the result in increasing hydrophobicity around the pyrene molecule by the C8 chain in tryptophan. Lifetime measurement were conducted for both ÃŽ ²MaltoOC12 and ÃŽ ²GlcOC8 in hexagonal phase and reported in (paper idayu). In both case, pyrene shows two distinct lifetime correspond to short component (0.87 – 0.97ns) and long component (11 – 51 ns) as an indication for the heterogeneity that the pyrene adopt in the system . Furthermo re, lifetime of ÃŽ ²MaltoOC12 which is 51 ns shows a higher isolation (caging effect) of pyrene in tail region as compared to ÃŽ ²GlcOC8 which has decay component of 11 ns. Comparison between the two type of lipid shows the effect of adding Trp-C8 with pyrene in ÃŽ ²MaltoOC12 (27 ns) is more prominent than in ÃŽ ²GlcOC8 (11.3 ns) system. In both cases implied the presence of C8 chain in Trp to cause a reduction in the local viscosity of tail region. However, in table 1, it is further observed that, the value for ÃŽ ²GlcOC8 is actually smaller than ÃŽ ²MaltoOC12. Since the smaller value of this ratio correspond towards more non-polar environment, it leads to a certain assumption that ÃŽ ²GlcOC8 were actually interact more with the pyrene due to shorter alkyl chain compared to ÃŽ ²MaltoOC12 which has more random and wobbling motion in the longer chain.(C8 vs C12). This increased the diffusion of oxygen and hence reduced the lifetime of pyrene CONCLUSION While it is tempting to cover all the other information about the unique nature of glycolipid self-assembly, this review provide a valuable insight on using fluorescence probes to investigate the local environment around two distinct group which is the hydrophilic head and hydrophobic tail of glycolipid. By comparing the fluorescence behavior of probes in solvent and in lipid, we will able to correlate those two in order to discover the local polarity in the lipid. While lifetime measurement in fluorescence uncover the hidden information that the steady-state measurement would not be able to obtain such as heterogeneity, flexibility and etc. These properties are crucial for biological processes such as ability of lipid in allowing different size of molecule to accommodate in the lipid. Understanding molecular self-assembly in microscopic scale and its behavior in different structure and phases will allow us to construct and produce efficient product for industrial application such as emulsifier and nano-carrier for drug delivery. ASSOCIATED CONTENT (Word Style â€Å"TE_Supporting_Information†). Supporting Information. A brief statement in nonsentence format listing the contents of material supplied as Supporting Information should be included, ending with â€Å"This material is available free of charge via the Internet at http://pubs.acs.org.† For instructions on what should be included in the Supporting Information as well as how to prepare this material for publication, refer to the journal’s Instructions for Authors. AUTHOR INFORMATION Corresponding Author * (Word Style â€Å"FA_Corresponding_Author_Footnote†). Give contact information for the author(s) to whom correspondence should be addressed. Present Addresses † If an author’s address is different than the one given in the affiliation line, this information may be included here. Author Contributions The manuscript was written through contributions of all authors. / All authors have given approval to the final version of the manuscript. / †¡These authors contributed equally. (match statement to author names with a symbol) . ABBREVIATIONS CCR2, CC chemokine receptor 2; CCL2, CC chemokine ligand 2; CCR5, CC chemokine receptor 5; TLC, thin layer chromatography. REFERENCES

Propaganda and Stereotyping Essay -- Media Stereotypes Stereotyping

Propaganda and Stereotyping Propaganda: a word that is commonly underestimated in its power. Confused with advertisement, people tend to take the disasters caused by propaganda lightly. One such disaster is the stereotype – a felicity confused with the truth. In this research paper, a closer attention will be given to the propaganda generation of stereotypes about a specific age group; how easily and believable stereotypes are carried by propaganda tactics on youth will be presented. Throughout this paper, a demonstration of the negative stereotypes on public opinion will be presented along with important methods in which stereotypes work in propaganda. The conclusion of this research paper will be highlighted through presenting credible research results and actual examples demonstrating the different stereotypes of today’s youth. At the end of this paper, it should be transparent that stereotypes are the brainchild of media through propaganda that uses its tactics and techniques to corrupt the pu blic minds. Prior to focusing on my example of youths’ stereotypes, it is a must to explain what propaganda is and how stereotypes have come to be a successful function of propaganda. Many people associate propaganda with advertisement, with television and radio ads. Indeed, these are forms of propaganda, but there other forms of communication that are far more complex, propaganda – simply because they are not perceived by audience as propaganda or better described as false or sometimes incomplete information presented as the truth without the knowledge of the audience. Some examples include false or incomplete news reporting, false habitual facts of certain groups of people, or even incomplete information about certain tendencie... ...ine at: , consulted on December 2001. Propaganda Techniques. â€Å"Internet†, in Disinfopedia Encyclopaedia. March edition, Center for Media & Democracy. Online at: , consulted on March 26 th, 2004 . Males, Mike (1994). â€Å" Bashing Youth: Media Myths about Teenagers†. Online at: , consulted on March/April, 1994. Joseph STRAUBHAAR and Robert LaROSE (2002). Media Now. Communications Media in the Information Age. 3rd Edition. Belmont, Wadsworth/Thompson Learning. KQED (1998). â€Å" YOUTH MEDIA CORPS: Youth Stereotypes, What are the Stereotypes?† Online at: , consulted on November 17 th, 1998 .

Blindness Essay -- essays research papers fc

The term blindness implies total or partial loss of vision involving both eyes. The exact level of vision defined as blindness, however, varies in different countries because of differing legal or social requirements. In the United States, blindness is defined as unimprovable vision of 20/200 (6/60) or worse. This means that an individual is generally considered blind who, even with the use of ordinary eyeglasses, can see no better at 20 ft (6 m) than a person with normal vision can see at 200 ft (60 m). On the other hand, the World Health Organization (WHO) Program Advisory Group on the Prevention of Blindness lists the vision level suggested as blindness as a visual acuity of less than 10/200 (3/60), which is twice as low as the U.S. definition. The WHO level of visual acuity is also described as the inability to count fingers in daylight at a distance of 10 ft (3 m), because in many regions a great number of people cannot receive formal eye examinations but may be tested by unspecialized personnel. From data available in the mid-1980s, the number of persons worldwide who have a visual acuity of less than 10/200 is estimated as 28 million. This level of handicap precludes an individual from functioning effectively in the community without special assistance and rehabilitation (see BLIND, EDUCATION OF THE). Were the definition of blindness instead taken as 20/200, as is done in a number of industrialized countries besides the United States, t... Blindness Essay -- essays research papers fc The term blindness implies total or partial loss of vision involving both eyes. The exact level of vision defined as blindness, however, varies in different countries because of differing legal or social requirements. In the United States, blindness is defined as unimprovable vision of 20/200 (6/60) or worse. This means that an individual is generally considered blind who, even with the use of ordinary eyeglasses, can see no better at 20 ft (6 m) than a person with normal vision can see at 200 ft (60 m). On the other hand, the World Health Organization (WHO) Program Advisory Group on the Prevention of Blindness lists the vision level suggested as blindness as a visual acuity of less than 10/200 (3/60), which is twice as low as the U.S. definition. The WHO level of visual acuity is also described as the inability to count fingers in daylight at a distance of 10 ft (3 m), because in many regions a great number of people cannot receive formal eye examinations but may be tested by unspecialized personnel. From data available in the mid-1980s, the number of persons worldwide who have a visual acuity of less than 10/200 is estimated as 28 million. This level of handicap precludes an individual from functioning effectively in the community without special assistance and rehabilitation (see BLIND, EDUCATION OF THE). Were the definition of blindness instead taken as 20/200, as is done in a number of industrialized countries besides the United States, t...

O’Connor’s Mission Essay -- Literary Analysis

It is a given that Flannery O’Connor is one of the most recognized southern female writers. This is mostly due to the pure religious content and reality in her writings. One of those stories, â€Å"A Good Man Is Hard to Find,† is one that combines her love of religion with her personal experience. It is a story on which its simple beginning tricks the reader, and its complex ending brings both questions and tears. What looks like just a field trip vacation turns into an unnecessary massacre for the purpose of understanding both religion and the human race. In â€Å"A Good Man Is Hard to Find,† O’Connor is able to leave impressions of her life on the location, characters, and scenes by the use of her love of religion and life experiences. Most of her life, Flannery O’Connor traveled around the United States, yet most of her life was spent in a place near Milledgeville, Georgia (May 17). On this detail, we can infer that it was no coincidence that she picked Georgia as her starting location for the story. It was a town she knew best, and could certainly describe to the perfection any places that she would’ve wanted to add. In the case of the story, O’Connor only describes one place, The Tower, and a little restaurant inside it where the family dines in. â€Å"The tower was a part stucco and part filling station and dance hall set in a clearing outside the Timothy† (O’Connor 302). Deferring from this description, O’Connor must have been in that place at least ten times; because a person who has never been to Georgia could never know what The Tower, its location and the Timothy were, nor would they have been able to guess on such a place. O’Connor included some of her l ife settings in order to make the story’s setting more realistic and credib... ...ically with â€Å"A Good Man Is Hard to Find,† Flannery O’Connor shows her biography to the world, and keeps her identity hidden while making a realistic story that we can all learn and ponder about. Works Cited "Flannery O’Connor." Georgia Literary Festival. Georgia College and state University, 12 Dec 2000. Web. 27 Mar 2012. . Magee, Rosemary M. Conversations with Flannery O'Connor. Mississippi: University Press of Mississippi, 1987. 5-10. Print. May, Charles â€Å"Career, Life, and Influence† Critical Insights Flannery O'Connor. 1st edition. Salem Press, 2012. 3-22. Print. O’Connor Flannery â€Å"A Good Man Is Hard To Find† The Norton Introduction To Literature. Shorter 10th ed. Booth, Alison, and Kelly J. Mays. New York, London: W.W. Norton & Co Inc., 2010. 299-310. Print.

Cover Letter Essay

I would like to apply for the role of Intermediate Support Developer in your organization as the details of the job role and company itself are very appealing to me. I have enclosed my resume for your consideration. I am an enthusiastic and high-achieving IT professional with a Masters of Computer Science. I have exceptional technical and analytical skills, with over 3 years’ experience in providing application support at level 1 and 2 for critical business applications with additional duties of unit and integration testing, technical documentation and prioritising and allocation of user tickets. I possess the ability to take initiative with a positive and friendly attitude. My excellent communication skill helps me understand user’s requirements to provide them with an excellent customer service. Working in a highly dynamic work environment, has given me the sound knowledge of interacting with business users and external stake holders, finding technical solutions, answering questions quickly, and leaving a mark of satisfaction in customer’s mind. You will find me to be positive, ready to learn and hardworking who has ability to multitask and communicate effectively with non-technical users. I believe my attitude, expertise, skills, and excellent time management skills will prove to be an asset to the organization. Thank you for your time and I look forward to hearing from you.

Night World : Witchlight Chapter 18

The ride to Charlotte passed in a blur. All Keller could remember was hanging on while Nissa did some of the wildest driving she'd ever experienced. They went offroad for a good deal of the way. It was one minute to midnight when they squealed into a parking lot in front of a long, low building. â€Å"Go in, go in!† Nissa said, slamming to a stop in front of a set of double doors. Keller and Galen and Winnie and Iliana ran. They burst into a large room that seemed very brightly lit. A sea of chairs with bodies sitting in them swam in front of Keller's eyes. Then she focused on a platform at the front. â€Å"Come on,† she said tersely. There were a number of people sitting at a table on the platform, facing the audience just like any ordinary panel, with glasses of water and microphones in front of them. But Keller recognized some of the people as she got closer, and they were anything but ordinary. That little dumpling-shaped woman with the round face was Mother Cybele. Mother of all the Witches, just as Grandma Harman had been Crone. With Grandma Harman dead, she was the witches' leader. The tall girl with the lovely features and the cafe au lait skin who sat beside her was Aradia. The blind Maiden of the Witches mentioned in the prophecies. And that regal-looking man with the golden hair and beard, sitting by the queenly woman with flashing green eyes†¦ They could only be the leaders of the First House of the shapeshifters. Galen's mother and father. There were others, too, important people from Circle Daybreak, but Keller didn't have time to focus on them. Mother Cybele was on her feet and speaking. She must have been a little short-sighted, because she didn't appear to see Keller and the others coming up on the side. Her voice was slow and concerned. â€Å"I'm afraid that since it's now past midnight-â€Å" Keller glanced at her watch. â€Å"It's just midnight now!† Mother Cybele looked up, startled, over her glasses. Every head on the panel turned. And every face in the audience was suddenly fixed on Keller's group. A low murmur like the humming of bees began, but it swelled very quickly to something like a muted roar. People were pointing openly as Keller ran up the steps to the stage. She glanced back at the others and realized why. They were a pretty sad-looking bunch. Every one of them was dirty and ragged. Winnie's strawberry-blond hair was dark red with blood on one side. Galen's sweater was in shreds. And she herself was filthy from the tunnel and all the dirt she'd encountered in the clearing. Only Diana looked reasonably clean, and that was probably because the glow kept you from focusing too closely. Mother Cybele gave a little cry of joy that sounded quite young, and she dropped the index cards she'd been holding. Aradia stood up, her beautiful blank eyes turned toward them, her entire face shining with joy. Galen's parents looked extremely startled and relieved. But some guy in a dark suit grabbed Keller's arm as she reached the top of the steps. â€Å"Who are you supposed to be?† he said. Keller shook him off and stood with her hair swirling around her. â€Å"We're the people who're bringing you the Wild Power,† she said. She spotted Nissa just coming in the door and beckoned to her. â€Å"And we're also the ones who killed the dragon.† The big room fell so silent that you could have heard a paper clip drop. â€Å"Well, actually, she killed the dragon,† Keller said, pointing to Diana. Aradia said in a hushed voice, â€Å"The Witch Child. She's come to us.† Iliana walked slowly up onto the stage and stood straight. â€Å"I didn't kill it alone,† she said. â€Å"Everybody helped, and especially Keller and Galen.† Galen's father's golden eyebrows went up, and Galen's mother gripped her husband's arm. Keller glanced sideways at Galen and saw that he was blushing. â€Å"They fought it and fought it until they were both almost dead. But then, when I used the blue fire, they got better again.† She said it so simply, speaking to Mother Cybele alone, or so it seemed. She didn't look in the least self-conscious, or in the least arrogant. I suppose she's used to having everybody looking at her, Keller thought. Mother Cybele actually clasped her little soft hands together and shut her eyes. When she opened them again, they were shining with tears. But all she said was, â€Å"Welcome, my child. Grandma Harman's last words were for you. She hoped you would find your power.† â€Å"She did,† Keller said. â€Å"Winnie helped her.† I didn't help her do that,† Winnie said candidly. â€Å"What she did back there and what she said. I just tried to show her how to use the orange fire. But when she started talking-† She shook her curly head. â€Å"I don't know where she got all that stuff about Hecate.† ‘It just came to me,† Iliana said. â€Å"I don't know. It was as if somebody was saying it to me, and I was just repeating it.† But who could have said it? Keller thought. Who else but somebody who was there the first time, when the dragons were put to sleep? Who else but Hecate Witch-Queen herself? Even though she'd been dead thirty thousand years. It's time for everything that's sleeping to wake back up again. Keller realized that she was hearing a noise from the crowd. At first, she thought that they were muttering in disbelief again, or maybe in annoyance at these people who were standing on the stage and chattering. Then it got louder and louder, and she realized it was applause. People were clapping and cheering and whistling. It was echoing off the ceiling and walls. And just when Keller thought it couldn't possibly get any louder, a new wave would come and prove her wrong. It took a long time for Mother Cybele to get them all quieted down. Then she turned to Keller and said formally, â€Å"So you've completed your mission?† Keller realized that it was a cue. And in the midst of the dizzy happiness she'd been feeling, something twisted in her heart. She kept it from showing on her face. She kept herself standing erect. â€Å"Yes,† she said to Mother Cybele. â€Å"I've brought the Witch Child.† She swallowed hard. â€Å"And here is the son of the First House of the shapeshifters,† Galen's father said. He stepped over to Galen and took his hand. His face was stern but glowing with pride. Galen's face was pale but set. He looked at Keller-for just one moment. And then he looked straight out at the audience with unseeing eyes. Mother Cybele looked toward Iliana. To take her hand, Keller supposed, and join it with Galen's. But Iliana was holding some whispered conversation with Aradia. When she finally turned around, Iliana said, ‘1 want Keller to do it. She's the one responsible for all this.† Keller blinked. Her throat was so swollen, it was impossible to swallow again. But she wouldn't have thought it of Iliana. Really, it seemed so pointlessly cruel to make her do it. But maybe she doesn't understand. That's it, she doesn't realize, Keller thought. She let out a careful, shaky breath and said, â€Å"Okay.† She reached for Diana's hand- And felt a stab in her palm. She looked down, astonished. Iliana had a knife in that hand, a perfectly serviceable little knife. She had cut Keller with it, and Keller was bleeding. In fact, Iliana seemed to be bleeding, too. â€Å"Sorry,† Iliana hissed. â€Å"Ick, I hate blood.† Then, grabbing Keller's hand again, she faced the audience and raised it up high. â€Å"There!† she said. â€Å"Now we're blood sisters. And she's already been like a sister to me, because she saved my life over and over. And if that's not good enough for an alliance between the witches and the shapeshifters, I don't know what is.† The entire audience gaped at her. Mother Cybele blinked rapidly. â€Å"Are you saying†¦Ã¢â‚¬  Galen's father looked incredulous. â€Å"Are you saying that you won't marry my son?† â€Å"I'm saying that she ought to marry your son- or promise to him, or whatever they want. She's the one he's in love with. And I don't see why you should make him miserable for his whole life just because you want the shapeshifters tied to the witches. Keller and I are tied together, and we always will be. And Galen, too. Why can't that be enough?† A sound was starting from the crowd again. Keller's heart seemed to soar on it. But she was still staring at Iliana, afraid to believe. â€Å"But†¦ what if the witches don't agree to it?† Galen's father said feebly. Iliana stamped her foot She actually did. Tm the Witch Child. They'd better listen to me. I didn't go through all of this for nothing.† Then the crowd was thundering applause even louder than before, and the wave seemed to sweep Keller right into Galen's arms. Sometime later, in the middle of a lot of hugging and kissing, Keller whispered to Iliana, â€Å"Are you sure?† ‘Td better be sure, don't you think? Or Galen's going to be pretty upset.† â€Å"Iliana-â€Å" ‘Tm sure,† Iliana whispered. She squeezed Keller. â€Å"I really do care about him. I guess I'm sort of in love with him, too. But I saw. I saw his face in the clearing when he thought you were dead. And I heard the way he said your name. And then†¦ I knew, you know? The two of you were meant to be. So I'm sure.† â€Å"A leopard?† Galen's mother said, shaking out her topaz-colored hair. â€Å"Why, dear, that's wonderful. Your great-great-grandmother was a leopard.† â€Å"You gave up being a bird for me,† Keller whispered in his ear. â€Å"I think I could learn to like running,† he murmured, and took the chance to touch his lips to her cheek. â€Å"No, ma'am, I'm really sorry I woke you up,† Keller said. â€Å"Yes, ma'am, I do know how late it is.† She strained to hear the voice on the other end of the phone. She had a finger in her ear to try and block out the noise of the wild celebration around her, but it wasn't doing much good. â€Å"Because I honestly don't think it's funny,† Diana's mother said. â€Å"The baby is just fine; he's been in his bed all night. Why would you think he wasn't?† â€Å"Well, ma'am, it's hard to explain†¦Ã¢â‚¬  â€Å"And now he's awake, and he's going to start crying-well, he's not crying. But now he wants to eat the phone†¦ Alex!† A voice on the other end squealed and said distinctly, â€Å"Kee-kee!† â€Å"Yeah, it's Kee-kee,† Keller said, startled. â€Å"Um, I'm glad you're okay, kid. And, see, I didn't go bye-bye after all. So you may think you're pretty smart, but you still have something to learn about precognition, hotshot. Right?† Keller added, â€Å"You know I thought for a minute once that you might be the Wild Power. But I guess you're just a good old-fashioned witch baby.† Diana, who was passing by, gave her a very strange look. â€Å"Keller, are you having a conversation with my baby brother?† â€Å"What exactly did the dragon say?† Mother Cybele asked anxiously. Although she looked like a big dove and her eyes were always kind, there was a firmness about her plump chin that Keller liked. â€Å"I asked who woke him up. And he said†-Keller reached for the exact words-â€Å"he said, ‘Someone you'll never know. A witch who isn't a witch. We made our own alliance.'† â€Å"A witch who isn't a witch,† Mother Cybele repeated. Aradia's face was sober. ‘I wonder who that could be. And where they are now.† Mother Cybele said quietly, â€Å"Time will tell.† â€Å"The police are already inside,† Nissa said, holding the cell phone to her ear as she talked to Keller. â€Å"I guess the kids at the party called them when they saw a panther. They've found the family†¦ Mr. and Ms. Ashton-Hughes and Jaime and Brett. They're taking them to the hospital.† She snapped the phone shut. â€Å"We'd better send some witches to the hospital. But as long as they're alive, they have a pretty good chance, don't you think? After all, we've got a Wild Power with healing fire. Now, can't you relax and try to enjoy yourself?† It was two days later. Keller was sitting in a sunny alcove in the safe house where Hiana and Galen and the others had been brought to protect them from the Night World. And to give them a chance to recover. It was nice to be still for a while. To sit and read†¦ and think. And it was even nicer to be able to do it with Galen around. He came in the door quietly-he always moved cat-quietly now. She smiled at him. He looked so wonderfully dear with his golden hair and fairytale looks and leopard-green eyes. â€Å"I wrote you a poem,† he said, sitting down beside her. â€Å"Well, no, that's not true. I kind of stole what your mother wrote and made it into†¦ something. I don't know what. But I think maybe it's what she really meant to say, after all.† Keller blinked at him, then looked down at the piece of paper he gave her. People die†¦ so love them every day. Beauty fades†¦ so look before it's gone. Love changes†¦ but not the love you give. And if you love, you'll never be alone. â€Å"Actually, I was going to say, ‘And you will always be alone†¦ so don't rely on others for your happiness, but don't stop loving, either, because then you'll end up empty and alone instead of alone and strong and able to give without worrying about what you're going to get back.' But that was kind of long, and it didn't scan,† he said. Keller stared down at the paper blindly. â€Å"I'm sorry,† he said. â€Å"If you don't like it-â€Å" Keller threw her arms around him, and her tears spilled over. â€Å"I'm going to burn the other one,† she said. â€Å"And I love you. Kiss me.† He grinned. â€Å"Yes, Boss.† And he did. One from the land of kings long forgotten; One from the hearth which still holds the spark; One from the Day World where two eyes are watching; One from the twilight to be one with the dark..

Protection of Vulnerable People: Safeguarding those with Mental Illness

Introduction Individuals with mental health conditions may suffer from neglect and abuse as a result of their condition (Taylor, 2006). Hence, the National Health Service (NHS) in the UK places emphasis on safeguarding these individuals and recognising them as a ‘vulnerable’ group. The Department of Health (2000) states that the act of ‘safeguarding’ is synonymous with protecting those who are more exposed to abuse and neglect. The main aim of this essay is to discuss safeguarding patients suffering from mental illness. The first part of this essay discusses vulnerability in this group. Factors that influence vulnerability and how these impact the health and wellbeing of these individuals will also be explored. The second part discusses multidisciplinary and multiagency interventions to protect and safeguard those with mental health conditions. The third part examines the safeguarding laws and policies that support and inform the work of a multi-disciplinary team. This w ill then be followed by a reflection of the findings of this essay and how these influence practice of a student nurse. Finally, a conclusion that summarises the key points raised in this essay will be done. Vulnerability of patients with mental health conditions Watkins (2008) observes that the limited ability individuals with mental health conditions to express themselves increase the risk of abuse. For example, patients might express their fears and anxiety through aggressive behaviour (RCN, 2008). When patients are placed in a new environment, such as a hospital setting, they might be unable to articulate their feelings and become anxious. This is aggravated when they could not see their family members or when nurses take over their families in providing for their care (RCN, 2008). McDonnell (2011) explains that is not uncommon for these patients to become defensive and aggressive when surrounded with ‘strangers’. Second, patients with mental illness often suffer from stigmatisation, discrimination and isolation (Lubkin and Larsen, 2011; Moran et al., 2013; Mestdagh and Hansen, 2014). Moran et al. (2013) states that isolation could aggravate the patient’s mental health condition since loss of social support increases risk of depression. Stigmatisation, on the other hand, increases vulnerability since patients might not access appropriate healthcare services due to negative perceptions of patients with mental illness (Mestdagh and Hansen, 2014). Individuals with a history of mental illness could also experience discrimination at work or when applying for employment (Lubkin and Larsen, 2011). All these factors influence the health and wellbeing of those with mental health condition. Lack of social support and inability of an individual to find an employment increase the risk of depression (Lubkin and Larsen, 2011). It is widely established (Cocker et al., 2014; Lubkin and Larsen, 2011) th at chronic depression is strongly associated with poor health outcomes such as development of cardiovascular diseases, hypertension, obesity, type 2 diabetes mellitus and other chronic conditions. Importantly, depression has been associated with poor adherence to medications or a care plan (Grenard et al., 2011). Hence, vulnerable individuals such as those with mental health conditions could suffer poorer health as a result of discrimination, stigmatisation and isolation. Multi-disciplinary and multiagency interventions to protect and safeguard those with mental health conditions A blended approach in caring for vulnerable individuals with mental health conditions has been promoted in the NHS (Transition Pathway, 2005). Different groups of healthcare professionals are involved in safeguarding those with mental health conditions. For instance, occupational therapists help patients engage in occupations that help restore meaning in their lives. On the other hand, therapists provide different types of counseling to assist individuals cope with their condition. For example, these therapists offer cognitive behavioural counseling or family therapy to help patients with their thought process or engage family members in the support and management of the individual (Gehart, 2012). Drawing from different literature, mental health nurses could also use current evidence to help inform care plans that are specific for the needs of a vulnerable individual. Meanwhile, a focus is made on patient-centred care (Transition Pathway, 2005) This means that vulnerable individuals participate in healthcare decisions regarding their health. Health and social care team members provide the needed support as they help students arrive at an informed decision. Today, there are many types of therapies and interventions for individuals with mental health condition. Watkins (2008) observes that each individual is unique and hence, blended approach and choices are necessary to create a healthcare plan specific for the individual. The chronic nature of mental health conditions also requires prolonged support and care from different healthcare team members. Similarly, multiple agencies have to coordinate care for each person. Many vulnerable individuals with mental health condition have to transition from supported care to independent living. Further, transition from adolescence to adulthood for vulnerable individuals could be a specially challenging time. The Department of Health (2011a) has provided the Pathways to getting a Life white paper to help health and social care practitioners coordinate care for those with mental health condition transition to independent living. One of the challenges when providing multidisciplinary and multi-agency care for vulnerable individuals is allowing patients to exercise autonomy while maintaining their safety. The Nursing and Midwifery Councils’ (NMC, 2008) code of conduct stresses the importance of respecting patient autonomy when making healthcare decisions. However, patient autonomy might be difficult to observe especially if choices of the patients could lead to poor health outcomes. On the other hand, patients are also encouraged to participate in healthcare decisions. While this is considered as best practice, some patients might be reluctant to participate in healthcare decisions (De Las Cuevas and Penate, 2014; Goggins et al., 2014; Hajizadeh et al., 2014). This might be due to poor levels of knowledge regarding their condition (Goggins et al., 2014) or inability to participate in healthcare decisions (De Las Cuevas and Penate, 2014). The former could be addressed through patient education while the latter through representation of a family member. Meanwhile, social care has an integral role in helping vulnerable individuals not only transition to independent living but also in assisting them find suitable employment. The partnership between health and social care ensures that individuals receive sufficient support when they return to their communities. Hence, empowering patients to take care of their own needs and to manage their condition prevents exacerbation of the condition or development of complications. Safeguarding laws and policies The policy ‘No Health without Mental Health’ (Department of Health, 2011b) acts as a guide for different healthcare professionals, social care workers and other stakeholders when providing care for individuals with mental health conditions. Specifically, this policy states that equitable treatment should be provided for vulnerable groups. This suggests that treatment and services should not only be patient-centred but also responsive to the immediate and long-term needs of the vulnerable individual. However, equitable mental health treatment for different groups of patients still remains a challenge in the NHS. For instance, Nzira and Williams (2008) argue that all individuals, regardless of their race or ethnicity, should enjoy equality in choice of their care providers and process. However, analysis of recent literature (Cantor-Graae and Selten, 2005; Kirkbride et al., 2008; Marmot, 2010) suggest that individuals from the black and minority ethnic groups do not enjoy the same ‘equality’ promoted in the Department of Health’s (2011b) policy. Incidence of mental health conditions is still higher in the black and minority ethnic group compared to the general white population in the UK. Further, this group also experiences social exclusion as a result of poor housing opportunities. There is evidence that poor housing and homelessness have been associated with poorer mental health (Pattereson et al., 2013). Hence, individuals with mental health conditions who happen to belong to the black and minority ethnic groups tend to have poorer health outcomes compared to their white counterparts (Kirkbride et al., 2008). Apart from evaluating the impact of the ‘No Health without Mental Health’ policy on vulnerable groups, it is also essential to investigate current legislations that safeguard those with mental health conditions. The Equality Act (UK Legislation, 2010) and the Mental Health Act 2007 (UK Legislation, 2007) both promote the rights of mental health patients. The first Act supports equality in the workplace. For instance, the Act states that employers are generally not allowed to ask about the disability of an individual before a job is offered. Although this does not exempt employers from asking questions on the health and background of future employees when absolutely necessary, this shows that equality is observed in the workplace. Meanwhile, the Mental Health Act 2007 (UK Legislation, 2007) introduces changes to the previous Mental Health Act 1983 (UK Legislation, 1983). This time, definition for mental health professionals is broadened to include different healthcare pro fessionals who are involved in the care of patients even without their consent. It should be noted that patients who pose a significant threat to others and to their own selves are admitted, detained and treated in hospital settings under this Act. Refection On reflection, this essay helped me realised the importance of increasing my knowledge on the needs of vulnerable patients with mental health conditions and the factors that promote their vulnerability. Healthcare professionals, particularly nurses, serve in the forefront of care. As leaders of care, I will facilitate the care and management of vulnerable patients in the future. This is only possible if I am aware on how cultural differences, stigmatisation, discrimination and isolation influence the trajectory of their condition. I realised that all these factors are crucial in promoting inequalities in healthcare. If I fail to address these factors, I will not be able to provide quality care to my patients. This essay also helps me appreciate the value of working in multidisciplinary teams and being aware of the roles of each team member. Since mental health conditions are complex, a blended approach is necessary to address individual needs. Vulnerability of an individual is increased when team members fail to consider and address the holistic needs of a patient. In my current and future practice, I should be aware of how I could contribute to effective team collaboration in order to reduce patient vulnerability. There is also a need to be aware of different safeguarding laws and policies for mental health patients. This will help me use these laws and policies to lobby for the rights of my patients. The Nursing and Midwifery Council (NMC, 2008) stresses the importance of patient safety and providing only quality care. Patient safety is observed when policies and laws on safeguarding are used to the fullest. On reflection, I should continue to become acquainted with different policies and legislations on safeguarding to ensure that the rights of my patients are protected. Specifically, this will help me find appropriate programmes or care pathways for my patients. On reflection, I should provide patient education to help patients make informed decisions regarding their care. This will not only empower my patients but also help them self-manage their own conditions. Conclusion This essay explores the concept of vulnerability and focuses on patients with mental health condition as a representative of the vulnerable group. These patients have additional challenges since mental illness is still strongly associated with discrimination, isolation and stigmatisation. Ethnic background also plays a role in their access to appropriate health and social care services. Those belonging to the black and minority ethnic groups have higher incidence of mental illness and less access to healthcare services compared to their white counterparts. The care pathway for vulnerable groups is supported by different health and social care agencies. Multidisciplinary and multi-agency team working are necessary to provide support to vulnerable groups. This essay demonstrates the importance of coordinating care and using a blended approach. Patient-centred care is highly promoted in the NHS since it is essential to design a care plan specific to the healthcare needs of an individual . Finally, this essay shows the importance of becoming acquainted with different policies and legislations on safeguarding. Knowledge on these policies and laws will help nurses exercise patient safety and quality care. Nurses will be able to identify appropriate health and social care services for each mental health service user. References: Cantor-Graae, E. & Selten, J. (2005) ‘Schizophrenia and migration: a meta-analysis and review’, American Journal of Psychiatry, 162, pp. 12-24. Cocker, F., Nicholson, J., Graves, N., Oldenburg, B., Palmer, A., Martin, A., Scott, J., Venn, A. & Sanderson, K. (2014) ‘Depression in working adults: comparing the costs and health outcomes of working when il’, PLoS One, 9(9): e105430 [Online]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25181469 (Accessed: 3 November, 2014). 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